The Agouti Signaling Protein (ASIP) gene interacts with the MC1R gene to control red (phaeomelanin) and black (eumelanin) pigment switching in dogs, affecting amount, type, and distribution of the two pigments.
The melanocortin 1 receptor (MC1R) gene controls production of the pigments eumelanin (black) and phaeomelanin (red/yellow). Six known variants of this gene are responsible for producing markings and coat colors including melanistic mask, grizzle/domino, black, and shades of red/yellow.
Spinal dysraphism (SD) in Weimaraner dogs is a genetic disorder present at birth that results from faulty embryonic development, leading to an abnormal gait as well as weakness and lack of coordination in the rear legs.
Progressive retinal atrophy (PRA) in the Sloughi is a late onset inherited rod-cone dysplasia that leads to visual impairment. Also known as rod-cone dysplasia 1a (or RCD1A).
GM1 gangliosidosis in the Shiba Inu breed (SI-GM1) is a progressive, lethal disorder caused by abnormal accumulation of a fatty molecule important for normal functioning of nerve cells in the brain.
Autosomal recessive amelogenesis imperfecta (ARAI), also known as familial enamel hypoplasia (FEH), is an inherited genetic disorder of tooth enamel that occurs in Samoyeds.
