Horse

Horse
Breed

Horse Embryo Pre-Implantation Genetic Diagnosis

Pre-implantation genetic diagnosis (PGD) is a procedure used to screen embryos recovered after uterine flush to determine sex and genetic traits through DNA testing prior to implantation in the uterus.

SynchroGait (DMRT3)

SynchroGait is a diagnostic DNA test for a genetic variant (A) that has a major impact on the gait and coordination of horses. The discovery by researchers in Sweden showed that the mutation “facilitates lateral gaits, ambling and pace, and inhibits the transition from trot or pace to gallop”. The gait A variant has been identified as a major genetic factor for performance in trotting horses and ability to perform the additional “flying pace” in Icelandic horses. 

Myosin-Heavy Chain Myopathy (MYHM)

Formerly known as IMM, Myosin-heavy chain myopathy (MYHM) is a muscle disease in Quarter Horses and related breeds that results in two distinct clinical disease presentations, immune-mediated myositis (IMM) and non-exertional rhabdomyolysis. Both presentations involve muscle loss or damage and are linked to the same genetic variant.

Skeletal Atavism

Skeletal atavism, an inherited bone development disorder found in Miniature Horses and Shetland Ponies, is characterized by severe angle anomalies and deformation of the front knee and hock. Affected horses typically display short legs, clubfootedness, and impaired movement.

Naked Foal Syndrome in Akhal-Teke

Naked foal syndrome (NFS) is an inherited disorder found in the Akhal-Teke breed and is characterized by hairlessness, abnormal teeth development, digestive disorders, persistent diarrhea, and laminitis-like problems.

Malignant Hyperthermia (MH)

Malignant hyperthermia (MH) is an inherited disease in which affected horses can be triggered by halogenated anesthetics, succinylcholine, stress, or excitement, which can induce a hyper-metabolic state characterized by symptoms including muscle contracture, elevated temperature, and an irregular heart rhythm.

Hyperkalemic Periodic Paralysis (HYPP)

Hyperkalemic periodic paralysis (HYPP) is an inherited disease of the muscles primarily found in Quarter Horses which is characterized by sporadic episodes of muscle tremors or paralysis.

Hereditary Equine Regional Dermal Asthenia (HERDA)

Hereditary equine regional dermal asthenia (HERDA) is an inherited skin condition primarily found in Quarter Horses that is characterized by hyperextensible skin, scarring, and severe lesions along the back of affected horses.

Occipitoatlantoaxial Malformation (OAAM)

Occipitoatlantoaxial malformation (OAAM), an inherited developmental condition primarily found in Arabian horses, causes abnormal development of the vertebrae and results in compression of the upper cervical cord with subsequent neurological damage.