Overview
The Veterinary Genetics Laboratory (VGL), in collaboration with Dr. Niels C. Pedersen and staff, has developed a panel of short tandem repeat (STR) markers that will assess genetic diversity across the genome and in the Dog Leukocyte Antigen (DLA) class I and II regions. This test panel will be useful to breeders who wish to track and increase genetic diversity of their breed as a long-term goal.
Genetic diversity testing of Borzoi is now in the data collection phase. During this phase, we will continue to test more registered dogs to build genetic data necessary to provide breeders with an accurate assessment of genetic diversity in their breed. This report is based on testing of 117 Borzoi. This number of dogs is probably sufficient to do a near-final genetic assessment of the breed. Allele and DLA haplotype frequencies will be updated as more Borzoi are tested. It is anticipated that new alleles at the 33 STR loci and additional DLA class I and II haplotypes will be identified in the future, but these will tend to be of much lower incidence than those detected in the present population.
Price
$85 one test per animal
$70 when combined with a diagnostic test
Results reported as:
Short tandem repeat (STR) loci: A total of 33 STR loci from carefully selected regions of the genome were used to assess genetic heterogeneity and existing genetic diversity within an individual as well as across the breed. The alleles inherited from each parent are displayed graphically to highlight heterozygosity, and breed-wide allele frequency is provided.
DLA haplotypes: STR loci linked to the DLA class I and II genes were used to identify genetic differences in regions regulating immune responses and self/non-self recognition. Problems with self/non-self recognition, along with non-genetic factors in the environment, are responsible for autoimmune disease.
Internal Relatedness: The IR value is a measure of genetic diversity within an individual that takes into consideration both heterozygosity of alleles at each STR loci and their relative frequency in the population. Therefore, IR values heterozygosity over homozygosity and uncommon alleles over common alleles. IR values are unique to each dog and cannot be compared between dogs. Two dogs may have identical IR values but with very different genetic makeups.
Report
Report issued April 21, 2020. Daily updated statistics are here.
