Quick Summary
Click here for Price and Turnaround Time
Phenotype: Affected puppies suffer from chronic infections resulting from a compromised immune system, are often smaller than their littermates and have developmental delays. Additionally, a narrow elongated skull and slender extremities have been observed in some affected dogs. Affected individuals can have infections from as early as 6 weeks of age, while a few may have mild clinical signs that are not observed until age 2 or older.
Mode of Inheritance: Autosomal recessive
Alleles: N = Normal, TNS = Trapped neutrophil syndrome
Breeds appropriate for testing: Border Collie
Explanation of Results:
- Dogs with N/N genotype will not have trapped neutrophil syndrome and cannot transmit this variant to their offspring.
- Dogs with N/TNS genotype will not be affected by trapped neutrophil syndrome, but are carriers. They may transmit this variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% trapped neutrophil syndrome-affected puppies.
- Dogs with TNS/TNS genotype will have trapped neutrophil syndrome.
Results of this test can be submitted to the OFA (Orthopedic Foundation for Animals)
Border Collie Health Panel
$80 per animal
An inherited neutropenia (decrease in white blood cells) has been identified in Border Collies. This disease, called trapped neutrophil syndrome (TNS), has been found to be caused by a mutation in the Vesicle Protein Sorting 13B (VPS13B) gene. Affected puppies suffer from chronic infections resulting from a compromised immune system, are often smaller than their littermates and have developmental delays. Additionally, a narrow elongated skull and slender extremities have been observed in some affected dogs. Affected individuals can have infections from as early as 6 weeks of age, while a few may have mild clinical signs that are not observed until age 2 or older. TNS is inherited as an autosomal recessive disease, thus both sexes are equally affected and 2 copies of the defective allele are required to produce the disease. The defective allele has been observed at a rate of 7-8% worldwide in Border Collies.
