Quick Summary
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Phenotype: The disease has late onset and is progressive. Affected animals develop multiple firm nodules (dermatofibrosis) in the skin typically by 6 years of age. They also develop bilateral, multifocal tumors (cystadenocarcinoma) in the kidney, although the timing and rate of growth is varied.
Mode of Inheritance: Autosomal dominant
Alleles: N = Normal, RCND = Renal cystadenocarcinoma and nodular dermatofibrosis
Breeds appropriate for testing: German Shepherd Dog
Explanation of Results:
- Dogs with N/N genotype will not have renal cystadenocarcinoma and nodular dermatofibrosis (RCND) and cannot transmit this variant to their offspring.
- Dogs with N/RCND genotype will have RCND. They may transmit this variant to 50% of their offspring. If bred to a N/N dog, 50% of offspring are predicted to be normal and 50% are predicted to have RCND. If bred to a N/RCND dog, only 25% of the offspring are predicted to be normal (no copies of the variant).
- Dogs with RCND/RCND genotype will have RCND and may not be viable (no RCND/RCND living dogs yet identified).
German Shepherd Health Panel
$130 per animal
Renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is an inherited cancer in German Shepherd Dogs. The disease has late onset and is progressive. Affected animals develop multiple firm nodules (dermatofibrosis) in the skin typically by 6 years of age. They also develop bilateral, multifocal tumors (cystadenocarcinoma) in the kidney, although the timing and rate of growth is varied.
RCND in the German Shepherd Dog breed results from a mutation in exon 7 (c.764A>G) of the folliculin (FLCN) gene. The disease is inherited in an autosomal dominant fashion, which means that males and females are equally affected and that a single copy of the defective gene will cause disease. Animals with two defective copies have not been identified, suggesting this genotype is incompatible with life.
Testing for RCND assists veterinarians with diagnosis of RNCD and helps breeders identify affected dogs among breeding stock to avoid producing affected puppies. Matings between two dogs that have one copy each of the RCND mutation are expected to produce only 25% of normal puppies with no copies of the mutation. This mating may also result in potential loss of embryos with two copies of the RCND mutation as it appears to be homozygous lethal.
