Susceptibility to Primary Closed Angle Glaucoma (PCAG) in Italian Greyhounds

Quick Summary

Primary closed angle glaucoma (PCAG) is a hereditary disease that results from a rapid build-up of pressure in the eye; if left untreated it will lead to blindness.

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Phenotype: Primary closed angle glaucoma (PCAG) is a hereditary disease that results from a rapid build-up of pressure in the eye, which causes loss of optic nerve function and retinal ganglion cell loss. The onset of this condition is sudden, painful, and if left untreated will lead to blindness. The average age of dogs at diagnosis is 3.9 years.

Mode of Inheritance: Autosomal recessive

Alleles: N = Normal, S = Glaucoma-associated linked mutations

Breeds appropriate for testing: Italian Greyhound

Explanation of Results:

  • Dogs with N/N genotype have a low risk of developing primary closed angle glaucoma (2%) and have no copies of the glaucoma-associated variants.
  • Dogs with N/S genotype have a low risk of developing primary closed angle glaucoma (2%), and are carriers of the glaucoma-associated variants. Matings between two carriers are predicted to produce 25% of puppies at higher risk of developing primary closed angle glaucoma.
  • Dogs with S/S genotype have two copies of the glaucoma-associated variants and are at increased risk of developing primary closed angle glaucoma (60 times more likely to develop). 

Results of this test can be submitted to the OFA (Orthopedic Foundation for Animals)

Turnaround Time
At least 15 business days; may be delayed beyond 15 business days if sample requires additional testing, or a new sample is requested.
Price

$55 single test per animal ($5 discount on 3 or more dogs)
$25 as additional health test on same animal

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Additional Details

In Italian Greyhounds, primary closed angle glaucoma (PCAG) is a hereditary disease that results from a rapid build-up of pressure in the eye, which causes loss of optic nerve function and retinal ganglion cell loss. The onset of this condition is sudden, painful, and if left untreated will lead to blindness. The average age of dogs at diagnosis is 3.9 years (range 0.5 to 6 years). Research by Dr. Niels Pedersen and Hongwei Liu at the University of California, Davis identified 2 linked mutations that are present in 75% of Italian Greyhounds with primary closed angle glaucoma.

Testing for PCAG allows owners to identify dogs at higher risk of this form of glaucoma and assists breeders to select breeding pairs to avoid producing offspring at higher risk.

 

Note: This test is specific for the 2 mutations associated with susceptibility to primary closed angle glaucoma in the Italian Greyhound breed. This test is not valid for other breeds.
Type of Sample
Cytology Brush - supplied by VGL at no additional charge (PREFERRED)
Mini mascara brushes - supplied by owner (click for accepted type)
Interdental/GUM brushes - supplied by owner (click for accepted types)

Species

Dog

Breed

Italian Greyhound
Type of Test
Health
Results Reported As
Test Result Susceptibility to Primary Closed Angle Glaucoma
N/N No copies of the glaucoma associated haplotype. Dog has a low risk (2%) of developing primary closed angle glaucoma.
N/S 1 copy of the glaucoma associated haplotype. Dog has a low risk (2%) of developing primary closed angle glaucoma. Breedings between carriers are expected to produce 25% higher risk offspring.
S/S 2 copies of the glaucoma associated haplotype. Dog is 60 times more likely to develop primary closed angle glaucoma.

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