Quick Summary
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Phenotype: Familial enamel hypoplasia (FEH) is characterized by enamel pitting and tooth discoloration; often teeth are unusually small, pointed, and prone to increasing gaps between teeth with age.
Mode of Inheritance: Autosomal recessive
Alleles: N = Normal, FEH = Familial enamel hypoplasia
Breeds appropriate for testing: Italian Greyhound
Explanation of Results:
- Dogs with N/N genotype will not have familial enamel hypoplasia and cannot transmit this variant to their offspring.
- Dogs with N/FEH genotype will not be affected by familial enamel hypoplasia, but are carriers. They will transmit this variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% familial enamel hypoplasia-affected puppies.
- Dogs with FEH/FEH genotype will have familial enamel hypoplasia and will transmit this variant to all of their offspring.
Results of this test can be submitted to the OFA (Orthopedic Foundation for Animals)
Italian Greyhound Health Panel
$105 per animal
Autosomal recessive amelogenesis imperfecta (ARAI) is an inherited genetic disorder of tooth enamel that occurs in Italian Greyhounds. It is commonly known to breeders as familial enamel hypoplasia (FEH). It is characterized by enamel pitting and tooth discoloration; often teeth are unusually small, pointed and prone to increasing gaps between teeth with age. There appears to be no association of FEH with periodontitis.
Dr. Niels Pedersen and his research group at the School of Veterinary Medicine, University of California, Davis identified the mutation associated with FEH in Italian Greyhounds. It is estimated that 14% of Italian Greyhounds are affected with FEH and 30% are carriers.
Testing for FEH assists owners and breeders in identifying affected and carrier dogs. Breeders can use results from the test as a tool for selection of mating pairs to avoid producing affected dogs.
