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Phenotype: Affected dogs typically display abnormal kidney function that is characterized by increased urination, excessive drinking and the presence of glucose in the urine despite normal blood glucose levels. Some dogs may also display weight loss, weakness and urinary incontinence.
Mode of Inheritance: Autosomal recessive
Alleles: N = Normal, FS = Fanconi Syndrome
Breeds appropriate for testing: Basenji
Explanation of results:
• Dogs with N/N genotype are expected to not have Fanconi syndrome. They cannot transmit this FS allele to any of their offspring.
• Dogs with N/FS genotype have one copy of this FS allele and are expected to not have Fanconi syndrome but are carriers. They will transmit this FS allele to 50% of their offspring. Matings between two carriers of FS may, on average, produce 25% of puppies with Fanconi syndrome.
• Dogs with FS/FS genotypes are homozygous for this FS allele and will display signs of Fanconi syndrome.
Basenji Health Panel
$105 per animal
Fanconi syndrome is a heritable kidney disorder that affects Basenjis. A genetic variant in the Fanconi associated nuclease 1 (FAN1) gene has been implicated as the causative mutation for Fanconi syndrome in the Basenji.
Affected dogs typically display abnormal kidney function around 4-8 years of age, characterized by reduced ability to reabsorb water, nutrients and electrolytes and resulting in increased urination and excessive drinking. Another common finding is the presence of glucose in the urine despite normal blood glucose levels. Some dogs may also display weight loss, weakness and urinary incontinence. If left untreated, the disease can progress to chronic kidney failure.
Testing recommendations: DNA testing for Fanconi syndrome can determine the genetic status of dogs. Dogs with one copy of the FS allele are normal but are carriers. Matings between two carrier dogs may, on average, produce 25% of puppies with Fanconi syndrome.