Devon Rex

This DNA-based parentage test uses microsatellite marker analysis to compare the DNA profile of an offspring to the profiles of possible parents.

This progressive retinal atrophy is an inherited late-onset blindness condition seen in Abyssinian, Somali, and some Ocicat and other breeds. Affected cats have normal vision at birth that slowly degenerates to blindness.

Feline polycystic kidney disease (PKD1) is a heritable form of polycystic kidney disease commonly seen in Persians and cats with Persian ancestry. Affected cats develop cysts on their kidneys, which often leads to renal failure at a later stage.

Four mutations that produce long-haired coats in domestic cats have been identified in a single gene. Three of the mutations are fairly breed specific, while the fourth is present in all long-haired cat breeds and crossbreds.

Dilute is an autosomal recessive trait that causes clumping and uneven distribution of pigment granules in the hair shaft, producing dilution of all coat colors.

Cats with colored 'points' have genetic mutations associated with temperature-sensitive pigment production. Pigment production is reduced in warmer areas of the body, leading to darker pigmentation in the cat's cooler extremities (paws, ears, etc.)

Cats with brown gene variants have reduced amounts of black pigment and appear brownish in color. 

The agouti signaling protein interacts with the melanocortin 1 receptor to switch between black and red pigments, creating a banding pattern in individual hairs. Mutations in the agouti signaling protein gene (ASIP) prevent this switch from occurring, resulting in hairs of uniform color.

The Devon Rex breed produces a curly coat and the Sphynx breed is nearly hairless. The nearly hairless coat of the Sphynx breed is recessive to normal coat, and the curly coat of the Devon Rex breed is recessive to the hairless Sphynx coat.